Hit-to-Lead Optimization CROs
Systematic refinement of initial screening hits into viable lead compounds through medicinal chemistry and SAR analysis.
32 organizations offer this service
WuXi AppTec
FeaturedLeading global pharmaceutical and medical device open-access capability and technology platform. WuXi AppTec provides services spanning from discovery through manufacturing across small molecules, biologics, and cell/gene therapies.
Medicilon
Chinese integrated drug discovery and development CRO providing medicinal chemistry, ADME/PK, pharmacology, toxicology, and CMC services from Shanghai operations.
Pharmaron
Integrated pharmaceutical R&D service platform offering drug discovery, preclinical, clinical, and commercial manufacturing services to biotech and pharma companies globally.
Evotec
Drug discovery and development company offering a range of discovery and preclinical services including target validation, hit identification, lead optimization, and ADME/PK.
Reaction Biology
Specialty CRO providing biochemical and cell-based assay services for drug discovery. Known for kinase profiling, epigenetic screening, and custom assay development.
Nuvisan
Fully integrated German CRO/CDMO offering drug discovery, non-clinical studies, pharmaceutical analysis, GMP manufacturing, and early-phase clinical trials from facilities in Germany and France.
Eurofins Panlabs Discovery
Eurofins Discovery division providing high-throughput in-vitro pharmacology screening, compound profiling, ADME assays, and bioanalytical services supporting drug discovery from target identification through lead optimization.
Southern Research
Nonprofit research organization providing drug discovery, preclinical development, and analytical services with deep expertise in oncology and infectious disease including BSL-3 capabilities.
BioDuro-Sundia
Global CRO/CDMO providing integrated drug discovery and development services including medicinal chemistry, ADME/PK, pharmacology, and process chemistry from US and China operations.
Viva Biotech
Chinese CRO/CDMO providing integrated drug discovery services including structure-based drug design, medicinal chemistry, ADME/PK studies, and biologics development from Shanghai operations.
Syngene International
Indian integrated research, development, and manufacturing services company serving pharma, biotech, and nutrition companies with discovery chemistry, biology, and manufacturing capabilities.
GVK Biosciences
Indian research services company providing medicinal chemistry, computational chemistry, biology, DMPK, and clinical development services for global pharma and biotech companies.
Jubilant Biosys
Integrated drug discovery and development services company providing medicinal chemistry, ADME/DMPK, pharmacology, and clinical research from India, US, and China operations.
AMRI Global
Contract research and manufacturing organization offering drug discovery, API synthesis, analytical development, and formulation services to global pharma and biotech.
Aragen Life Sciences
Hyderabad-headquartered integrated CRDMO providing CRO and CDMO solutions for small and large molecules to 450+ global pharma and biotech clients with 3,000+ professionals.
ChemPartner
Shanghai-headquartered CRO/CDMO offering integrated drug discovery chemistry, biology, and biologics development services including ADC and recombinant protein production.
Fidelta (now Selvita)
Croatian integrated drug discovery CRO providing medicinal chemistry, biology, DMPK, and preclinical development services, now part of Polish CRO Selvita Group.
Suven Life Sciences
Hyderabad-headquartered pharmaceutical CRO with dedicated clinical trials division providing drug discovery, early-phase clinical, and regulatory support with strong CNS expertise.
Ricerca Biosciences (Olon Ricerca)
Contract research organization providing discovery, preclinical, and development chemistry services including API synthesis, safety pharmacology, and medicinal chemistry.
Selvita Group
Polish integrated drug discovery CRO providing medicinal chemistry, biology, DMPK, computational chemistry, and preclinical services with 1,000+ scientists across Europe.
Novascreen Biosciences Corp
Hanover, Maryland-based drug screening CRO offering high-throughput receptor binding, enzyme inhibition, and functional cell-based assays for hit-to-lead optimisation programmes.
Aptuit Verona
Verona, Italy-based integrated drug discovery and development centre providing medicinal chemistry, DMPK, safety assessment, and pharmaceutical development under the Evotec umbrella.
ShangPharma
One of China's earliest chemistry-focused CROs offering integrated drug discovery, DMPK, and pharmaceutical development services globally.
Hande Biotech
Chinese CRO and CDMO offering integrated preclinical biology, in-vitro pharmacology, and early drug discovery services for domestic and multinational pharma clients.
Bellen Chemistry
Chinese CDMO specializing in custom synthesis of building blocks, advanced intermediates, and reference compounds for global pharmaceutical R&D, with a catalog of over 40,000 compounds.
Fidelta Croatia
Zagreb-based drug discovery CRO (Selvita Group) providing integrated medicinal chemistry, ADME/PK, and in vitro biology services for hit-to-lead and lead optimization programs.
Sai Life Sciences
Hyderabad-based Indian CDMO providing integrated drug discovery, development, and manufacturing services with capabilities spanning medicinal chemistry through commercial API supply.
GVK Bio Discovery
Hyderabad-based Indian CRO providing contract research in discovery chemistry, biology, DMPK, and clinical development with integrated data analytics platform GOSTAR.
BioDuro-Sundia Shanghai
Shanghai campus of BioDuro-Sundia providing integrated discovery and development services including medicinal chemistry, DMPK, biology, and preclinical development for global biotech.
Oncodesign Services
European preclinical CRO in Dijon, France, specializing in oncology, inflammation, and infectious disease drug discovery including targeted radiotherapy programs.
Aurigene Pharmaceutical Services
Dr. Reddy's wholly-owned integrated CRO and CDMO for small molecules and biologics, combining 650+ Indian scientists with GMP manufacturing in the UK, Mexico, and India.
Mosaic Biosciences
Boulder-based biologic discovery CRO integrating antibody discovery, protein engineering, function-first screening, and early developability assessment for complex biotherapeutics.